Tabriz University of Medical Sciences Health Promotion Perspectives 2228-6497 16 1 2026 06 06 Cross-Border Cooperation for One Health in Central Asia: Strengthening Systems and Securing Futures through Regional Health Diplomacy 14 21 10.34172/hpp.45299 EN Vijay Kumar Chattu https://orcid.org/0000-0001-9840-8335 Nidhi Nagabhatla https://orcid.org/0000-0002-5941-2048 Alma Nurtazina https://orcid.org/0009-0001-2904-6083 Philippe De Lombaerde https://orcid.org/0000-0002-6546-6771 Altay Dyussupov https://orcid.org/0000-0003-0875-1020 Journal Article 10.34172/hpp.45299 2025 10 10 2025 11 28 Central Asia faces mounting challenges from emerging infectious diseases, antimicrobial resistance, and food insecurity. This article examines regional cooperation in the One Health approach as a transformative strategy for strengthening regional health security through Regional Health Diplomacy (RHD). The Central Asia One Health Framework for Action represents a paradigmatic shift from fragmented national health strategies to an integrated regional approach. We argue that ‘RHD’ serves as the critical catalyst for implementing the One Health Framework. We call for the strategic implications to extend beyond health outcomes to encompass broader regional integration, establishing Central Asia as a pioneer in multi-sectoral health governance and a potential knowledge hub for One Health implementation.